VasoMax - PerformaxLabsTest

VasoMax

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Increasing blood flow is an integral part of any serious weightlifter’s regimen. Benefits include: increased nutrient delivery, improved waste product removal, and swelling of the muscle, which leads to satellite cell recruitment and muscle growth. To achieve optimal levels of vascularity and muscle fullness, you need the right formula. Which is why Performax Labs is proud to present VasoMaxTM, the next generation of blood flow enhancement products. VasoMaxTM brings together the best vasodilatory ingredients, such as Vaso6, GSNO(S-nitrosoglutathione), and Sceletium tortuosum – all of which are clinically researched and presented at efficacious doses. To keep it free of stimulants, we recruited two of the top nootropics available – Alpha-GPC and Huperzine A – to keep your focus razor sharp. Add in GlycerPump – a patented superhydrator for maximal muscle fullness, and you have the best non-stim, pump-fueled, pre-workout possible!

  • GlycerPump – A patented, super-concentrated form of glycerol that drives super-hydration for intense, prolonged workouts.
  • VASO6™ – Studies show VASO6™ leads to 50% vasodilation at a 300mg dose, the exact dose found in every scoop of VasoMax
  • Sceletium tortuosum – A phosphodiesterase inhibitor that induces vasodilation and enhances cognitive function.
  • Alpha-GPC – Best choline donor available – increases whole body and brain choline for production of acetylcholine – the “learning” neurotransmitter.
  • Huperzine A – Inhibits acetylcholinesterase so that acetylcholine will not be broken down and will work longer and stronger.

By combining evidence-based ingredients that can increase, maintain, and prolong blood flow for hours, VasoMaxTM is truly in a class all its own. Adding GlycerPump to this formula really put it over the top, since you are both hydrating the body for the workout ahead and driving that swole muscle fullness that will activate muscle growth. Anytime you’re hitting the gym, make sure you’re hitting it harder and stronger with VasoMaxTM!

GlycerPump

GlycerPump is a patented, super-concentrated form of glycerol, which is an osmolyte that will improve hydration via increased intracellular uptake into the muscle. The resultant swelling of the muscle will also stimulate satellite cell recruitment, resulting in muscle growth.

  • A recent meta-analysis by Goulet et al. (2007) concluded that hyper-hydration with glycerol enhances prolonged exercise performance under hot conditions.

 

VASO6™

VASO6™ increases nitric oxide production. More nitric oxide in the blood stream results in endothelial-dependent relaxation (EDR). This is valuable for delivering more oxygen to muscle for greater ATP production and power, as well as nutrient delivery

  • Schlaich 2000 Reference U.S. Patent No 6,706,756 BI, Fig.7 Grape seed extract fractions were separated and bioassayed for EDR activity using the rat aorta preparation. The compounds that exhibited the most EDR activity are contained in VASO6 at levels shown to induce 50% relaxation in the rat aorta.

 

GSNO (S-nitrosoglutathione)

GSNO plays a critical role in nitric oxide (NO) signaling and is a source of bioavailable NO. GSNO can help regulate NO by serving as a stable and mobile NO pool, since it can release NO at different rates. Since NO is a labile gas, it cannot be stored as such, so that having a stable pool of NO could benefit the body in terms of vasodilation.

  • In addition to vasoactive benefits, Rauhala et al. (2005) reviewed how GSNO cupplementation is also neuroprotective.

 

Alpha-GPC

Alpha-GPC is the most that is highly bioavailable source of choline on the market. It also traverses the blood-brain barrier, such that it increases acetylcholine in the brain and can therefore enhance cognitive function and neuronal health. Its non-choline metabolite – glycerophosphate – can improve membrane structure and function.

  • Increased growth hormone and upper body power output were observed after supplementation with alpha-GPC.

 

Sceletium tortuosum

This traditional herb has been used for stress relief for centuries. By inhibiting both serotonin and phosphodiesterase 4, it is able to improve cognition, mood, and blood flow.

  • Terburg et al. (2013) showed a reduction in state anxiety after administration of Sceletium tortuosum is response to a cognitive task
  • Chiu and colleagues (2014) demonstrated that consuming Sceletium tortuosum improved executive function and cognitive flexibility: two cognitive domains necessary for athletic performance.

 

Huperzine A

Huperzine A is an acetylcholinesterase inhibitor, which is an enzyme that breaks down acetylcholine. Through this process, huperzine A increases acetylcholine – the “learning” neurotransmitter that is also responsible for muscular contraction.

  • Zhao et al. (2003) showed the potent ability of huperzine A to inhibit acetylcholinesterase in the cerebral cortex, hippocampus, and striatum.

 

Vitamin C

Vitamin C is the major antioxidant molecule in the diet. Oxidative stress and free radicals can reduce nitric oxide via inactivation of endothelial tissue – the site of nitric oxide production. Vitamin C can combat free radicals (which are naturally produced from exercise) and keep endothelial tissue functioning and nitric oxide flowing.

  • D’Uscio et al. (2003) demonstrated that vitamin C can increase nitric oxide synthase activity by stabilizing tetrahydrobiopterin, an important cofactor for the enzyme’s function.

Q: How do I take Performax Labs’ VasoMax?

A: Take one serving before each workout. VasoMax is efficaciously dosed, which means that one serving will do the trick, but it is safe enough to be taken more than once per day, such as for multiple daily workouts.

Q: Why do I want to stimulate blood flow?

A: Blood is the transportation system of the body. To effectively deliver oxygen and nutrients to the muscles and remove waste products, proper blood flow is needed. During exercise, there is more demand for oxygen and nutrients, and the body naturally produces free radicals and inflammatory mediators since exercise is “stressful.” Vasodilation can improve this transport.

Q: What other Performax Labs products can I stack with Performax Labs’ VasoMax?

A: VasoMax stacks amazingly well with HyperMax XT to give you the stimulant plus pump combo – our PWO Stack – or can be combined with Nootropimax and IntraMax for our Low Stim Stack.

Q: When is the best time to take Performax Labs’ VasoMax?

A: The best time is 20-30 minutes before your workout to give the molecules time to be absorbed and to stimulate blood flow. There are no stimulants in this product, so it can be effectively taken morning, noon, and night.

GlycerPump

  1. Ross, M.L., et al., Effects of lowering body temperature via hyperhydration, with and without glycerol ingestion and practical precooling on cycling time trial performance in hot and humid conditions. Journal of the International Society of Sports Nutrition, 2012. 9(1): p. 55.
  2. Nelson, J.L. and R.A. Robergs, Exploring the potential ergogenic effects of glycerol hyperhydration. Sports medicine, 2007. 37(11): p. 981-1000.
  3. Freund, B.J., et al., Glycerol hyperhydration: hormonal, renal, and vascular fluid responses. J Appl Physiol (1985), 1995. 79(6): p. 2069-77.
  4. Koenigsberg, P.S., et al., Sustained hyperhydration with glycerol ingestion. Life sciences, 1995. 57(7): p. 645-653.
  5. Hitchins, S., et al., Glycerol hyperhydration improves cycle time trial performance in hot humid conditions. European journal of applied physiology and occupational physiology, 1999. 80(5): p. 494-501.
  6. Johnson, V., A. Carlson, and A. Johnson, Studies on the physiological action of glycerol on the animal organism. American Journal of Physiology–Legacy Content, 1933. 103(3): p. 517-534.
  7. Goulet, E.D., et al., A meta-analysis of the effects of glycerol-induced hyperhydration on fluid retention and endurance performance. International journal of sport nutrition and exercise metabolism, 2007. 17(4): p. 391-410.

 

VASO6™

  1. Schlaich 2000 Reference U.S. Patent No 6,706,756 BI, Fig.7 Grape seed extract fractions were separated and bioassayed for EDR activity using the rat aorta preparation. The compounds that exhibited the most EDR activity are contained in VASO6 at levels shown to induce 50% relaxation in the rat aorta.

 

GSNO (S-nitrosoglutathione)

  1. Singh, S., et al., The chemistry of the S-nitrosoglutathione/glutathione system. Proceedings of the National Academy of Sciences, 1996. 93(25): p. 14428-14433.
  2. Snyder, A.H., et al., Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis. American journal of respiratory and critical care medicine, 2002. 165(7): p. 922-926.
  3. Khan, M., et al., S-Nitrosoglutathione Increases Benefit of Motor Exercise on Functional Recovery and Stimulates Neurorepair Mechanisms Following Experimental Stroke in Rats. 2012, Am Heart Assoc.
  4. Rauhala, P., T. Andoh, and C.C. Chiueh, Neuroprotective properties of nitric oxide and S-nitrosoglutathione. Toxicology and applied pharmacology, 2005. 207(2): p. 91-95.

 

Alpha-GPC

  1. De Jesus Moreno Moreno, M., Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. Clin Ther, 2003. 25(1): p. 178-93.
  2. Ziegenfuss, T., J. Landis, and J. Hofheins, Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. Journal of the International Society of Sports Nutrition, 2008. 5(S1): p. P15.
  3. Kawamura, T., et al., Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. Nutrition, 2012. 28(11-12): p. 1122-6.
  4. Troesch, B., et al., Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods. Am J Clin Nutr, 2009. 89(2): p. 539-44.

 

Sceletium tortuosum

  1. Terburg, D., et al., Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus. Neuropsychopharmacology, 2013. 38(13): p. 2708-16.
  2. Chiu, S., et al., Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evid Based Complement Alternat Med, 2014. 2014: p. 682014.
  3. Nell, H., et al., A randomized, double-blind, parallel-group, placebo-controlled trial of Extract Sceletium tortuosum (Zembrin) in healthy adults. J Altern Complement Med, 2013. 19(11): p. 898-904.

 

Huperzine A

  1. Zhao, Q. and X.C. Tang, Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. European journal of pharmacology, 2002. 455(2): p. 101-107.
  2. Kozikowski, A.P. and W. Tueckmantel, Chemistry, pharmacology, and clinical efficacy of the Chinese nootropic agent huperzine A. Accounts of chemical research, 1999. 32(8): p. 641-650.
  3. Bai, D., Development of huperzine A and B for treatment of Alzheimer’s disease. Pure and applied chemistry, 2007. 79(4): p. 469-479.
  4. Ved, H.S., et al., Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport, 1997. 8(4): p. 963-967.
  5. Peng, Y., et al., Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. Neuroscience, 2007. 150(2): p. 386-395.

 

Vitamin C

  1. Taddei, S., et al., Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation, 1998. 97(22): p. 2222-2229.
  2. d’Uscio, L.V., et al., Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circulation research, 2003. 92(1): p. 88-95.
  3. Ting, H.H., et al., Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation, 1996. 97(1): p. 22.
  4. Huang, A., et al., Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. Journal of biological chemistry, 2000. 275(23): p. 17399-17406.

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