Caffeine is the most commonly used stimulant in the world. Its effectiveness doesn’t stop at adrenaline and focus – it increases calorie burning and fat burning, while also improving power output, aerobic, and anaerobic exercise. More calories burned means more weight lost.
- Astrup et al. (1990) demonstrated that caffeine can increase metabolic rate (calorie burn) by 32.4 kcal/hr, and increased fat burning.
- In trained athletes, Schneiker et al. (2006) observed that caffeine induced an increase in peak power of 7% and an increase in total work of 8.5%.
- Glaister et al. (2012) found that caffeine improved sprinting time by 1.4% during a multiple sprint running test.
Eria Jarensis Extract
Eria jarensis contains multiple phenethylamines, such as N-phenethyl-dimethylamine, which are trace amines that effectively regulate metabolism and insulin sensitivity.
- Raab et al. (2016) showed that a trace amine receptor (TAAR1) is a regulator of metabolism via action on hormone secretion in the gastrointestinal tract and pancreatic islets (the site of insulin and glucagon production).
B-phenylethylamine is a trace amine that affects multiple neurotransmitters to improve energy, focus and mood, including catecholamines such as adrenaline and noradrenaline. These arousal hormones will cause increases in caloric expenditure, leading to weight loss.
- Borowsky et al. (2001) showed that trace amine receptors can be found in specific brain areas where B-phenylethylamine has demonstrated catecholaminergic activity.
- A meta-analysis (Stohs et al., 2012) reports multiple studies that indicate that trace amines can increase metabolic rate, fat burning, and energy expenditure.
- Paterson (1993) observed that phenylethylamine activated noradrenaline receptors in a sympathomimetic fashion, independent of noradrenaline.
Hordeum vulgare is a naturally-occurring source of hordenine, an adrenergic-like compound that improves energy and focus. Through its action as a noradrenaline reuptake inhibitor, it enhances the bioavailability, action, and long-lasting effect of noradrenaline, an arousal hormone that can lead to caloric expenditure and weight loss.
- Barwell et al. (1989) observed the effects of hordenine on noradrenaline and its reuptake, suggesting that it would be effective when combined with other enhancers of noradrenaline release.
- Rossato (2011) investigates how the activity of supplements on adrenergic receptors can elicit thermogenic (calorie burning) effects via stimulation of noradrenaline.
Paradoxine Grains of Paradise
Grains of paradise (Afromamum melegueta) is a commonly used spice in certain parts of the world. It shares some chemical similarities to Ginger, and its main active constituent, 6-paradol, has demonstrated weight loss benefits via increased caloric expenditure.
- Sugita et al. (2013) observed that supplementation with grains of paradise increased caloric burn through activation of brown adipose tissue, a type of fat tissue that encourages fat burning through heat production.
Nelumbo Nucifera (std. to Higenamine)
Also known as sacred lotus, this plant can benefit weight loss in a number of ways, such as reduced fat accumulation in cells and reduced appetite. Its main constituent, Higenamine, is a known Beta-adrenergic agonist, similar to ephedrine.
- Siegner et al. (2010) observed potent lipolytic activity with lotus administration, which leads to less fat in tissues and more available for burning.
- Du et al. (2010) showed that lotus leaf extract leads to appetite reductions of 20-29%.
- Higenamine is demonstrated to be an effective agonist of beta-adrenergic receptors in a range of tissues, a mechanism similar to other fat burners ephedrine and synephrine.
Coleus Forskohlii (Root) Extract
An important botanical in Ayurvedic medicine, Coleus forskohlii is known for its fat-burning effects, as well as improving overall body composition.
- In a study of 30 men, Godard et al. (2005) observed that lean mass and bone mass increased while fat mass decreased after Coleus foskohlii supplementation.
- Jagtap et al. (2011) showed that coleus can improve body mass index (BMI) while increasing high-density lipoprotein – the good cholesterol.
A pigment found in brown seaweed, fucoxanthin is a fat-soluble compound that is stored in adipose tissue and inhibits fat cell growth and differentiation.
- Sixteen weeks of supplementation with fucoxanthin resulted in body weight loss of 12.1 pounds in the treatment group, along with increased metabolic rate and lower fat in the blood (Abidov, 2009).
Black Pepper Extract
Piperine inhibits cytochrome P450 enzymes, which play essential roles in the elimination of many compounds. Therefore, piperine can increase the time that certain compounds stay in the bloodstream, thereby improving their effectiveness.
- Piperine has demonstrated increased bioavailability of bioactive compounds of up to 2000%.
Rauwolfia is a natural source of rawolscine, a stereoisomer of yohimbine. It acts similarly to yohimbine as an alpha-2 adrenergic antagonist and as an agonist for serotonin receptors. As such, it stimulates the central nervous system to improve fat loss.
- Perry et al. (1981) discuss how rawolscine is a potent antagonist of alpha-2 adrenergic receptors, which aids the body’s ability to maintain fat loss, making rawolscine an ideal partner with other fat-burning ingredients.