MassMax - PerformaxLabsTest

MassMax

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Title

Anabolic maximization: how do make your hormones work for you? Though androgenic hormones like testosterone are important, your body uses a wide range of other anabolic hormones to regulate muscle growth, and you want these hormones to be firing on all cylinders. That is why Performax Labs is excited to bring you MassMax XTTM – the most exciting, cutting-edge anabolic available. We have combined the best drivers of muscle growth with compounds designed to improve digestion, absorption, and bioavailability. MassMax XTTM contains an HPLC extract of Rhaponticum Carthamoides, with a wide range of ecdysteroids. Cell and animal studies clearly demonstrate the anabolic potential of ecdysteroids, and human studies suggest that the right combination of pure ecdysteroids are needed to unlock that potential. That is why our highly purified HPLC extract of whole plant Rhaponticum Carthamoides is so important, because other products using inferior methods to extract ecdysteroids cannot compare to the clinically proven muscle mass growth of MassMax XTTM!

  • Rhaponticum Carthamoides extract – A whole plant extract containing 20-hydroxyecdysone – the most active ecdysteroid, according to comparison studies.
  • Epicatechin – Potent muscle and strength builder that acts by decreasing myostatin and increasing follistatin, as well as increasing blood flow.
  • Methyl Palmitate/Methyl Oleate – Fatty acid esters from honeybee drone milk with potent anabolic effects.
  • Atractylodes Lancea Rhizome – Chinese medicinal root that improves gastric emptying and intestinal motility for better absorption.
  • Sodium caprate – Absorption enhancer via increased opening of cellular tight junctions.
  • Piperine – Extracted from black pepper, it slows down the elimination of compounds so their bioavailability is increased.

By combining anabolic enhancers with bioavailability activators, we have created a truly unique formula that can create and sustain a hormonal milieu which will drive lean mass growth. By tapping into nature’s methods of sustained growth through the utilization of extracts discovered in honeybee drone milk and in the processes of insect molting, this formula is revolutionizing how gains in muscle mass are achieved. Maximize your hard-earned gains in the gym with the best-in-class anabolic activator: MassMax XTTM!

Rhaponticum Carthamoides Extract

Rhaponticum Carthamoides consists of a wide range of ecdysteroids. Ecdysterone has demonstrated potent anabolic effects without increasing androgens, like testosterone.

  • Simakin et al. (1988) demonstrated that ecdysterone increased muscle mass up by 6-7% while simultaneously decreasing fat mass by 10%.
  • The anabolic effects of ecdysteroids have been demonstrated in multiple studies, whether in vitro, in animal models, or in humans.
  • Human performance studies from using whole plant Rhaponticum Carthamoides demonstrated significant improvements in muscle mass, fat mass, and work capacity, while studies from inferior sources did not.

 

Epicatechin

Epicatechin, which is found naturally in dark chocolate and green tea, in another potent muscle and strength builder. It acts by both decreasing myostatin in the body and by increasing follistatin, both of which result in muscle growth.

  • Gutierrez-Salmean et al. found that 7 days of treatment with 25mg of epicatechin resulted in a 50% increase of the follistatin/myostatin ratio in humans, as well as a significant increase in handgrip strength.
  • Epicatechin activates nitric oxide synthase, which is an enzyme that activates nitric oxide production. Nitric oxide causes vasodilation, leading to enhanced blood flow.

 

Methyl Palmitate

Methyl palmitate is a fatty acid ester that is naturally found in honeybee drone milk. It has demonstrated potent anabolic effects.

  • In a study from the University of Szeged, Hungary (2014), 10 days of treatment with drone milk significantly increased testosterone levels and muscle mass, as measured by the levator ani muscle in rats [12]. Methyl palmitate and methyl oleate were determined to be the active ingredients in the drone milk.

 

Methyl Oleate

Methyl oleate is another fatty acid ester found in honeybee drone milk that works synergistically with methyl palmitate to increase androgens.

  • In the study by Seres et al. mentioned above (2014), the administration of methyl palmitate alone reproduced the anabolic effect, but both fatty acid esters were needed to increase testosterone.

 

Atractylodes Lancea Rhizome

Traditionally used in Chinese medicine to remedy low appetite, gastric distress, and nausea, studies have demonstrated that atractylodes improves gastric emptying and intestinal motility.

  • Fujitsuka et al. (2011) showed that Atractylodes works by enhancing ghrelin secretion. Ghrelin is known as the “hunger hormone” for its ability to control hunger, and it increases anabolic hormones, such as growth hormone.

 

Camellia Sinensis (standardized to 50% EGCG)

This potent tea extract is standardized to 50% epigallocatechin-3-gallate (EGCG), which is the most potent of the tea catechins. Similar to epicatechin mentioned above, EGCG modulates many anabolic and catabolic factors, such as myostatin.

  • Meador et al. (2015) observed that EGCG supplementation increased muscle mass via expression of anabolic factors and reduced protein breakdown in the muscle through multiple mechanisms, including myostatin.

 

Sodium Caprate

Sodium caprate is a well-documented absorption enhancer. Increased intestinal absorption can occur transcellularly (across the cell) or paracellularly (between cells). Sodium caprate functions by opening spaces in bicellular and tricellular tight junctions which increases paracellular permeability.

  • Soderholm et al. (1998) were able to use electron microscopes to observe the opening of tight junctions between cells via sodium caprate administration.

 

Black Pepper Extract (95% Piperine)

Piperine inhibits cytochrome P450 enzymes, which play essential roles in the elimination of many compounds. Therefore, piperine can increase the time that certain compounds stay in the bloodstream, thereby improving their effectiveness. This is especially important for compounds that the body metabolizes quickly, such as ecdysteroids.

  • Piperine has demonstrated increased bioavailability of bioactive compounds of up to 2000%.
  • Piperine downregulates enzymes that eliminate bioactive compounds from the body, so their bioavailability is enhanced.
  • Piperine increases absorption by decreasing intestinal motility rate, thereby allowing other bioactive compounds more time to be absorbed.

Q: How do I take Performax Labs’ MassMax?

A: Take one serving (2 capsules) twice daily with your highest protein containing meals.

Q: Is taking Performax Labs’ MassMax safe?

A: Yes, all the ingredients can be found in nature and have been carefully sourced and tested for safety, as well as the final formula.

Q: Are there steroids in Performax Labs’ MassMax?

A: No anabolic steroids were used in the formulating of MassMax. Rhaponticum carthamoides contains ecdysteroids, which means that it is chemically similar to some anabolic steroids, but it is plant-derived from an herb commonly used in Russian and Siberian folk medicine.

Q: What other Performax Labs products can I stack with MassMax?

A: Check out our Mass Stack, which includes MassMax, AlphaMax, and SlinMax to truly maximize testosterone, anabolics, and insulin for nutrient repartitioning.

Q: When is the best time to take Performax Labs’ MassMax?

A: In the morning is best to take advantage of your body’s natural hormonal diurnal cycle.

Rhaponticum Carthamoides

  1. Simakin, S. Y. (1988). The Combined Use of Ecdisten and the Product’Bodrost’during Training in Cyclical Types of Sport.Scientific Sports Bulletin2.
  2. Chermnykh, N. S., Shimanovskiĭ, N. L., Shutko, G. V., & Syrov, V. N. (1988). The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles.Farmakologiia i toksikologiia51(6), 57.
  3. Gorelick-Feldman, J., MacLean, D., Ilic, N., Poulev, A., Lila, M. A., Cheng, D., & Raskin, I. (2008). Phytoecdysteroids increase protein synthesis in skeletal muscle cells.Journal of agricultural and food chemistry56(10), 3532-3537.
  4. Azizov AP, S.R., Chubarova AV, The effect of elton, leveton, fitoton and adapton on the work capacity of experimental animals. Eksp Klin Farmakol, 1998. 61(3).
  5. Azizov AP, S.R., Chubarova AV, Effects of leuzea tincture and leveton on humoral immunity of athletes. Eksp Klin Farmakol, 1997. 60(60): p. 47-48
  6. Wilborn, C. D., Taylor, L. W., Campbell, B. I., Kerksick, C., Rasmussen, C. J., Greenwood, M., & Kreider, R. B. (2006). Effects of methoxyisoflavone, ecdysterone, and sulfo-polysaccharide supplementation on training adaptations in resistance-trained males.Journal of the International Society of Sports Nutrition3(2), 1.
  7. Timofeev, N. P. (2008). ECDYSTEROIDS: USAGE IN MEDICINE, SOURCES, AND BIOLOGICAL ACTIVITY (REVIEW).Functional Foods for Chronic Diseases: Advances in the Development of Functional Foods, 171.
  8. Parr, M.K., Botre, F., Nab, A., Hengevoss, J., Diel, P., & Wolber, G. (2015). Ecdysteroids: A novel class of anabolic agents. Biol Sport, 32(2), 169-173.
  9. Hunyadi, A., Gergely, A., Simon, A., Tóth, G., Veress, G., & Báthori, M. (2007). Preparative-scale chromatography of ecdysteroids of Serratula wolffii Andrae.Journal of chromatographic science45(2), 76-86.

 

Epicatechin

  1. Gutierrez-Salmean, G., et al., Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem, 2014. 25(1): p. 91-4.
  2. Ramirez-Sanchez, I., et al., (−)-Epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension, 2010. 55(6): p. 1398-1405.
  3. McDonald, C., et al., Epicatechin enhances mitochondrial biogenesis, increases dystrophin and utrophin, increases follistatin while decreasing myostatin, and improves skeletal muscle exercise response in adults with Becker muscular dystrophy (BMD). Neuromuscular Disorders, 2015. 25: p. S314-S315.
  4. Nogueira, L., et al., (–)‐Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. The Journal of physiology, 2011. 589(18): p. 4615-4631.
  5. Barnett, C.F., et al., Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (−)-epicatechin in healthy volunteers. Food & function, 2015. 6(3): p. 824-833.
  6. Ras, R.T., P.L. Zock, and R. Draijer, Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis. PLoS One, 2011. 6(3): p. e16974.

Methyl Palmitate/Methyl Oleate

  1. Seres, A., et al., Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate. Journal of ethnopharmacology, 2014. 153(2): p. 446-453.
  2. Yucel, B., et al., The effects of Apilarnil (Drone bee larvae) administration on growth performance and secondary sex characteristics of male broilers. Journal of Animal and Veterinary Advances, 2011. 10(17): p. 2263-2266.
  3. Bogdanov, S., The bee products: the wonders of the bee hexagon, bee product science. 2011, July.
  4. Mutsaers, M., Bee products: properties, processing and marketing. 2005: Agromisa Foundation/Technical Centre for Agricultural and Rural Cooperation (CTA).

 

Atractylodes Lancea Rhizome

  1. Kimura, Y. and M. Sumiyoshi, Effects of an Atractylodes lancea rhizome extract and a volatile component β-eudesmol on gastrointestinal motility in mice. Journal of ethnopharmacology, 2012. 141(1): p. 530-536.
  2. Fujitsuka, N., et al., Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival. Translational Psychiatry, 2011. 1(7): p. e23.
  3. Yu, K.-W., et al., Intestinal immune system modulating polysaccharides from rhizomes of Atractylodes lancea. Planta medica, 1998. 64(08): p. 714-719.
  4. Yu, K.-W., et al., Structural characterization of intestinal immune system modulating new arabino-3, 6-galactan from rhizomes of Atractylodes lancea DC. Carbohydrate polymers, 2001. 46(2): p. 147-156.
  5. Yu, K.-W., et al., Characterization of pectic polysaccharides having intestinal immune system modulating activity from rhizomes of Atractylodes lancea DC. Carbohydrate polymers, 2001. 46(2): p. 125-134.
  6. Taguchi, I., et al., Structure of oligosaccharide side chains of an intestinal immune system modulating arabinogalactan isolated from rhizomes of Atractylodes lancea DC. Carbohydrate research, 2004. 339(4): p. 763-770.

 

Camellia Sinensis (standardized to 50% EGCG)

  1. Meador, B., et al., The Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCg) Attenuates Skeletal Muscle Atrophy in a Rat Model of Sarcopenia. The Journal of frailty & aging, 2015. 4(4): p. 209-215.
  2. Kerksick, C.M., et al., Changes in skeletal muscle proteolytic gene expression after prophylactic supplementation of EGCG and NAC and eccentric damage. Food and chemical toxicology, 2013. 61: p. 47-52.
  3. Wimmer Jr, R.J., Green Tea (EGCG), Insulin, IGF-1 Suppression of Atrophy Associated Transcription Factor Foxo1 Activity in Skeletal Muscle and Mathematical Modeling of Nuclear Influx Efflux of Foxo1 in Skeletal Muscle. 2014, University of Maryland, Baltimore.
  4. Ras, R.T., P.L. Zock, and R. Draijer, Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis. PLoS One, 2011. 6(3): p. e16974.

 

Sodium Caprate

  1. Krug, S.M., et al., Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells. Biomaterials, 2013. 34(1): p. 275-282.
  2. Anderberg, E.K., T. Lindmark, and P. Artursson, Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharmaceutical research, 1993. 10(6): p. 857-864.
  3. Soderholm, J.D., et al., Reversible increase in tight junction permeability to macromolecules in rat ileal mucosa in vitro by sodium caprate, a constituent of milk fat. Digestive diseases and sciences, 1998. 43(7): p. 1547-1552.
  4. Söderholm, J.D., et al., Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn’s disease. Gut, 2002. 50(3): p. 307-313.
  5. MORISHITA, M., et al., Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin. Biological and Pharmaceutical Bulletin, 1993. 16(1): p. 68-72.

 

Black Pepper Extract (95% Piperine)

  1. Bajad, S., et al., Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice. Planta Med, 2001. 67(2): p. 176-9.
  2. Rao, V.R., et al., Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA. Nat Prod Res, 2011. 25(13): p. 1288-94.
  3. Shoba, G., et al., Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med, 1998. 64(4): p. 353-6.
  4. Han, H.K., The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin Drug Metab Toxicol, 2011. 7(6): p. 721-9.

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