Oxymax

These are the FAQ's and Science behind our thermogenic fatburner

Take one serving (one capsule) daily in the morning.

Check out our Cut stack which combines OxyMax with SlinMax, HyperMax, and VasoMax for optimized hormonal regulation and performance in the gym.

Though chemically similar to some dangerous drugs, the trace amines used in this formula – Eria jarensis and B-phenylethylamine HCl – are very safe. Due to their specific chemical structures, these compounds act similarly to other neurotransmitter activators, but without the side effects or dangers.

In the morning is best to set metabolism for the day and so htat the stimulants don’t disrupt sleep patterns. Preferably take OxyMax on an empty stomach, but utilize appropriately within the confines of your diet.

Science

In this section we will cover each and every ingredient

Caffeine is the most commonly used stimulant in the world. Its effectiveness doesn’t stop at adrenaline and focus – it increases calorie burning and fat burning, while also improving power output, aerobic, and anaerobic exercise. More calories burned means more weight lost.

Astrup et al. (1990) demonstrated that caffeine can increase metabolic rate (calorie burn) by 32.4 kcal/hr, and increased fat burning.

In trained athletes, Schneiker et al. (2006) observed that caffeine induced an increase in peak power of 7% and an increase in total work of 8.5%.

Glaister et al. (2012) found that caffeine improved sprinting time by 1.4% during a multiple sprint running test.

Eria jarensis contains multiple phenethylamines, such as N-phenethyl-dimethylamine, which are trace amines that effectively regulate metabolism and insulin sensitivity.

Raab et al. (2016) showed that a trace amine receptor (TAAR1) is a regulator of metabolism via action on hormone secretion in the gastrointestinal tract and pancreatic islets (the site of insulin and glucagon production).

B-phenylethylamine is a trace amine that affects multiple neurotransmitters to improve energy, focus and mood, including catecholamines such as adrenaline and noradrenaline. These arousal hormones will cause increases in caloric expenditure, leading to weight loss.

Borowsky et al. (2001) showed that trace amine receptors can be found in specific brain areas where B-phenylethylamine has demonstrated catecholaminergic activity.

A meta-analysis (Stohs et al., 2012) reports multiple studies that indicate that trace amines can increase metabolic rate, fat burning, and energy expenditure.

Paterson (1993) observed that phenylethylamine activated noradrenaline receptors in a sympathomimetic fashion, independent of noradrenaline.

Hordeum vulgare is a naturally-occurring source of hordenine, an adrenergic-like compound that improves energy and focus. Through its action as a noradrenaline reuptake inhibitor, it enhances the bioavailability, action, and long-lasting effect of noradrenaline, an arousal hormone that can lead to caloric expenditure and weight loss.

Barwell et al. (1989) observed the effects of hordenine on noradrenaline and its reuptake, suggesting that it would be effective when combined with other enhancers of noradrenaline release.

Rossato (2011) investigates how the activity of supplements on adrenergic receptors can elicit thermogenic (calorie burning) effects via stimulation of noradrenaline.

Grains of paradise (Afromamum melegueta) is a commonly used spice in certain parts of the world. It shares some chemical similarities to Ginger, and its main active constituent, 6-paradol, has demonstrated weight loss benefits via increased caloric expenditure.

Sugita et al. (2013) observed that supplementation with grains of paradise increased caloric burn through activation of brown adipose tissue, a type of fat tissue that encourages fat burning through heat production.

Also known as sacred lotus, this plant can benefit weight loss in a number of ways, such as reduced fat accumulation in cells and reduced appetite. Its main constituent, Higenamine, is a known Beta-adrenergic agonist, similar to ephedrine.

Siegner et al. (2010) observed potent lipolytic activity with lotus administration, which leads to less fat in tissues and more available for burning.

Du et al. (2010) showed that lotus leaf extract leads to appetite reductions of 20-29%.

Higenamine is demonstrated to be an effective agonist of beta-adrenergic receptors in a range of tissues, a mechanism similar to other fat burners ephedrine and synephrine.

A pigment found in brown seaweed, fucoxanthin is a fat-soluble compound that is stored in adipose tissue and inhibits fat cell growth and differentiation.

Sixteen weeks of supplementation with fucoxanthin resulted in body weight loss of 12.1 pounds in the treatment group, along with increased metabolic rate and lower fat in the blood (Abidov, 2009).

Piperine inhibits cytochrome P450 enzymes, which play essential roles in the elimination of many compounds. Therefore, piperine can increase the time that certain compounds stay in the bloodstream, thereby improving their effectiveness.

Piperine has demonstrated increased bioavailability of bioactive compounds of up to 2000%.

Rauwolfia is a natural source of rawolscine, a stereoisomer of yohimbine. It acts similarly to yohimbine as an alpha-2 adrenergic antagonist and as an agonist for serotonin receptors. As such, it stimulates the central nervous system to improve fat loss.

Perry et al. (1981) discuss how rawolscine is a potent antagonist of alpha-2 adrenergic receptors, which aids the body’s ability to maintain fat loss, making rawolscine an ideal partner with other fat-burning ingredients.

References

These are the references to the exact studies, down the page we have created these formulations around.

Caffeine Anhydrous
Astrup, A., et al., Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American journal of clinical nutrition, 1990. 51(5): p. 759-767.
Glaister, M., et al., Caffeine supplementation and multiple sprint running performance. Med Sci Sports Exerc, 2008. 40(10): p. 1835-40.
Schneiker, K.T., et al., Effects of caffeine on prolonged intermittent-sprint ability in team-sport athletes. Med Sci Sports Exerc, 2006. 38(3): p. 578-85.
Beaven, C.M., et al., Dose effect of caffeine on testosterone and cortisol responses to resistance exercise. Int J Sport Nutr Exerc Metab, 2008. 18(2): p. 131-41.
Anderson, D.E. and M.S. Hickey, Effects of caffeine on the metabolic and catecholamine responses to exercise in 5 and 28 degrees C. Med Sci Sports Exerc, 1994. 26(4): p. 453-8.
Harpaz, E., et al., The effect of caffeine on energy balance. J Basic Clin Physiol Pharmacol, 2017. 28(1): p. 1-10.
Gurley, B.J., S.C. Steelman, and S.L. Thomas, Multi-ingredient, caffeine-containing dietary supplements: history, safety, and efficacy. Clin Ther, 2015. 37(2): p. 275-301.
Goldstein, E.R., et al., International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr, 2010. 7(1): p. 5.
Spriet, L.L., Caffeine and performance. Int J Sport Nutr, 1995. 5 Suppl: p. S84-99.


Eria Jarensis Extract
Raab, S., et al., Incretin-like effects of small molecule trace amine-associated receptor 1 agonists. Molecular Metabolism, 2016. 5(1): p. 47-56.
Kato, M., et al., ß-Phenylethylamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D 2 receptor mechanism. European journal of pharmacology, 2001. 418(1): p. 65-71.
Narang, D., et al., Trace amines and their relevance to psychiatry and neurology: a brief overview. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2011. 21(1): p. 73-79.
Paterson, I., The potentiation of cortical neuron responses to noradrenaline by 2-phenylethylamine is independent of endogenous noradrenaline. Neurochemical research, 1993. 18(12): p. 1329-1336.
Shannon, H.E., E.J. Cone, and D. Yousefnejad, Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. J Pharmacol Exp Ther, 1982. 223(1): p. 190-6.
Ono, H., H. Ito, and H. Fukuda, 2-Phenylethylamine and methamphetamine enhance the spinal monosynaptic reflex by releasing noradrenaline from the terminals of descending fibers. The Japanese Journal of Pharmacology, 1991. 55(3): p. 359-366.

B-phenylethylamine HCl
Borowsky, B., et al., Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A, 2001. 98(16): p. 8966-71.
Stohs, S.J., H.G. Preuss, and M. Shara, A Review of the Human Clinical Studies Involving Citrus aurantium (Bitter Orange) Extract and its Primary Protoalkaloid p-Synephrine. International Journal of Medical Sciences, 2012. 9(7): p. 527-538.
Astrup, A., L. Breum, and S. Toubro, Pharmacological and clinical studies of ephedrine and other thermogenic agonists. Obes Res, 1995. 3 Suppl 4: p. 537S-540S.
Kato, M., et al., ß-Phenylethylamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D 2 receptor mechanism. European journal of pharmacology, 2001. 418(1): p. 65-71.
Shannon, H.E., E.J. Cone, and D. Yousefnejad, Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. J Pharmacol Exp Ther, 1982. 223(1): p. 190-6.
Paterson, I., The potentiation of cortical neuron responses to noradrenaline by 2-phenylethylamine is independent of endogenous noradrenaline. Neurochemical research, 1993. 18(12): p. 1329-1336.

Hordeum Vulgare
Barwell, C.J., et al., Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. J Pharm Pharmacol, 1989. 41(6): p. 421-3.
Nedergaard, O.A. and E. Westermann, Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea-pig. Br J Pharmacol, 1968. 34(3): p. 475-83.
Rossato, L.G., et al., Synephrine: from trace concentrations to massive consumption in weight-loss. Food Chem Toxicol, 2011. 49(1): p. 8-16.
Frank, M., et al., Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse. Equine Vet J, 1990. 22(6): p. 437-41.
Hapke, H.J. and W. Strathmann, [Pharmacological effects of hordenine]. Dtsch Tierarztl Wochenschr, 1995. 102(6): p. 228-32.
Pellati, F. and S. Benvenuti, Chromatographic and electrophoretic methods for the analysis of phenethylamine [corrected] alkaloids in Citrus aurantium. J Chromatogr A, 2007. 1161(1-2): p. 71-88.
Servillo, L., et al., Tyramine Pathways in Citrus Plant Defense: Glycoconjugates of Tyramine and Its N-Methylated Derivatives. J Agric Food Chem, 2017. 65(4): p. 892-899.
Konczol, A., et al., Blood-brain barrier specific permeability assay reveals N-methylated tyramine derivatives in standardised leaf extracts and herbal products of Ginkgo biloba. J Pharm Biomed Anal, 2016. 131: p. 167-174.


Paradoxine Grains of Paradise
Sugita, J., et al., Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. Br J Nutr, 2013. 110(4): p. 733-8.
Kazeem, M.I., et al., Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria. Asian Pac J Trop Biomed, 2012. 2(9): p. 727-32.
El-Halawany, A.M., et al., Screening for estrogenic and antiestrogenic activities of plants growing in Egypt and Thailand. Pharmacognosy Res, 2011. 3(2): p. 107-13.
Nwozo, S.O. and B.E. Oyinloye, Hepatoprotective effect of aqueous extract of Aframomum melegueta on ethanol-induced toxicity in rats. Acta Biochim Pol, 2011. 58(3): p. 355-8.

Nelumbo Nucifera (std. to Higenamine)
Siegner, R., et al., Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle. Nutr Metab (Lond), 2010. 7: p. 66.
Du, H., et al., Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. J Biomed Sci, 2010. 17 Suppl 1: p. S42.
Kimura, I., et al., Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria. Jpn J Pharmacol, 1994. 66(1): p. 75-80.
Liu, W., et al., Effects of higenamine on regulation of ion transport in guinea pig distal colon. Jpn J Pharmacol, 2000. 84(3): p. 244-51.
Park, C.W., K.C. Chang, and J.K. Lim, Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacodyn Ther, 1984. 267(2): p. 279-88.

Coleus Forskohlii (Root) Extract
Godard, M.P., B.A. Johnson, and S.R. Richmond, Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res, 2005. 13(8): p. 1335-43.
Jagtap, M., H.M. Chandola, and B. Ravishankar, Clinical efficacy of Coleus forskohlii (Willd.) Briq. (Makandi) in hypertension of geriatric population. Ayu, 2011. 32(1): p. 59-65.
Greenway, F.L. and G.A. Bray, Regional fat loss from the thigh in obese women after adrenergic modulation. Clin Ther, 1987. 9(6): p. 663-9.
Henderson, S., et al., Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J Int Soc Sports Nutr, 2005. 2: p. 54-62.


Fucoxanthin
Abidov, M., et al., The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes Metab, 2010. 12(1): p. 72-81.
Xia, S., et al., Production, characterization, and antioxidant activity of fucoxanthin from the marine diatom Odontella aurita. Mar Drugs, 2013. 11(7): p. 2667-81.
Rajauria, G. and N. Abu-Ghannam, Isolation and Partial Characterization of Bioactive Fucoxanthin from Himanthalia elongata Brown Seaweed: A TLC-Based Approach. Int J Anal Chem, 2013. 2013: p. 802573.
Maeda, H., et al., Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model. Mol Med Rep, 2009. 2(6): p. 897-902.
Nishikawa, S., M. Hosokawa, and K. Miyashita, Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A(y) mice. Phytomedicine, 2012. 19(5): p. 389-94.


Black Pepper Extract
Bajad, S., et al., Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice. Planta Med, 2001. 67(2): p. 176-9.
Rao, V.R., et al., Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA. Nat Prod Res, 2011. 25(13): p. 1288-94.
Shoba, G., et al., Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med, 1998. 64(4): p. 353-6.
Han, H.K., The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin Drug Metab Toxicol, 2011. 7(6): p. 721-9.

Rauwolfia Vomitoria
Perry, B.D. and D.C. U’Prichard, [3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol, 1981. 76(4): p. 461-4.
Rockhold, R.W. and F. Gross, Yohimbine diastereoisomers: cardiovascular effects after central and peripheral application in the rat. Naunyn Schmiedebergs Arch Pharmacol, 1981. 315(3): p. 227-31.
Arthur, J.M., S.J. Casanas, and J.R. Raymond, Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochem Pharmacol, 1993. 45(11): p. 2337-41.
Wainscott, D.B., et al., [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol, 1998. 357(1): p. 17-24.
Kohli, J.D. and N.N. De, Pharmacological action of rauwolscine. Nature, 1956. 177(4521): p. 1182.