Creatinol-O-Phosphate: Improve Strength and Endurance

06 . 01 . 2017 by aaron

Creatinol-O-Phosphate: Improve Strength and Endurance

What is Creatinol-O-Phosphate?

Creatinol-O-Phosphate (N-methyl-N-(beta-hydroxyethyl) guanidine O-phosphate) or COP for short, is not creatine in a technical sense. Though it does possess structural similarities to creatine, it is thought to act as a creatine precursor and provides completely different effects. Creatinol-O- Phosphate has been shown to assist in stabilizing intracellular and extracellular pH levels during exercise and for this reason, it has become a popular performance enhancing compound in the supplement industry due to being able to prolong anaerobic glycolysis.


What are the benefits of supplementing with Creatinol-O-Phosphate?

As stated previously the main advantage of COP supplementation is its ability to extend anaerobic glycolysis. Anaerobic glycolysis (AG) is the energy system used by the body that transforms glucose to lactate when limited amounts of oxygen are available. AG is only an effective means of energy production during short, intense exercise (such as weight lifting), and provides energy for approximately 10 seconds to 2 minutes.  As AG glycolysis continues metabolic by-products such as lactic acid and hydrogen ions begin to accumulate which causes a drop in muscle pH.  This creates an acidic environment which leads to failed muscular contractions and fatigue.

From a scientific perspective, Creatinol-O-Phosphate fights the adverse effects of AG by acting as an intracellular buffer that counteracts the rise in muscle acidity. This allows muscular contractions to continue for longer periods of time than would normally occur. Prolonged contractions subject muscles to increased time under tension and lead to the recruitment of more and larger muscle fibers (Type IIA and IIX).  This activates satellite cells in skeletal muscle, elicits a dramatic anabolic response, and leads to rapid new gains in muscle size and strength.

In theory, COP may also lead to increased rates of ATP resynthesis.  When ATP is used for energy in the body, it loses a phosphate molecule and becomes ADP.  COP may be able to donate its phosphate molecule to ADP to reform ATP at a more rapid rate.  This could lead to increased muscular endurance and time to exhaustion.


What does the research say?

Here is a brief summary of a few key studies on Creatinol-O-Phosphate

  • A study conducted by Gaggino et al. found subjects who supplemented with COP were able to maintain muscular contractions despite increased lactic acid levels.
  • De Gasperi et al. observed COP supplementation increased muscular time under tension after only seven days.

When is the best time to take Creatinol-O-Phosphate?

To take advantage of COP’s ergogenic benefits, it is best consumed 15-30 minutes before exercise with carbohydrates and/or fast digesting proteins such as whey isolates.  This ensures maximal muscle tissue saturation.

Are there any adverse side effects?

No serious adverse events have been reported by individuals supplementing with COP. Numerous human trials have been conducted demonstrating it is 100% safe. However, anyone who has a health condition or is taking a prescription medication should first consult with a doctor before using Creatinol-O-Phosphate.

Bottom Line:

Creatinol-O-Phosphate is a novel compound that allows muscles to contract longer and harder in the presence of acidic metabolic waste products caused by anaerobic glycolysis. To recap COP can help:

  • Prolong anaerobic glycolysis
  • Buffer the negative effects of lactic acid and hydrogen ions
  • Increase muscle time under tension
  • Recruit more and larger muscle fibers
  • Increase muscle size, strength, and endurance
  • Rapidly replenish ATP stores

Ready to try Creatinol-O-Phosphate?

      COP can be found in Performax’s innovative and potent pre-workout PowerMaxXT. The full clinical doses of clinically validated ingredients found in PowerMaxXT work in synergy to        amplify size, strength, power, endurance and produce massive pumps. When looking for a    comprehensive and extremely effective pre-workout, look no further than PowerMaxXT from    industry-leading Performax.


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