Ingredient Spotlight: S7-seven plant based ingredients to boost nitric oxide

S7™ | Ingredient Spotlight


The supplement industry catches a lot flack from the non-supplement using public, but one thing that can’t be said of the industry is that it’s lackadaisical.

Each year, the industry debuts new ingredients vying for inclusion in the next wave of best-selling pre workouts, protein powders, and more.

2019 was no exception to new ingredients either as we saw the release of several intriguing ingredients, one of which is included in our latest version of VasoMax.

That ingredient is S7.

You may have heard of this ingredient, but may not be sure how it works.

That’s where this quick-hitting guide to all things S7 comes in.

Let’s start with the basics...

What is S7?

S7 is a proprietary combination of seven plant-based ingredients developed by FutureCeuticals that has been clinically shown to increase nitric oxide (NO) by 230% in humans.[1]

The seven ingredients comprising S7 are[1]:

S7 Chart of ingredients

But, in case you’re not quite familiar with them, FutureCeuticals sourced (extracted) these bioactive compounds from the following seven foods[1]:


  • Green Coffee Bean
  • Green Tea 
  • Turmeric Extract
  • Tart Cherry
  • Blueberry
  • Broccoli
  • Kale

What Does S7 Do?

As we mentioned above, S7 was shown in a small clinical trial to enhance the body’s own production of nitric oxide without the addition of nitrates or other nitric oxide precursors, such as L-Citrulline.[1]


So, how does S7 do this?


It all revolves around a phenomenon known as “redox signaling.”


“Redox signaling” is a biological process that serves as a protective measure against oxidative damage, such as the kind imposed by excessive reactive oxygen species (ROS).[2]


When the body is in “redox homeostasis”, the rate of ROS production are generally in balance with the scavenging rates of the body’s antioxidant defense systems.


However, when the body is not able to maintain this balance, meaning the body’s scavenging ability can’t keep up with the rates of ROS production, NO production can be impaired.


As a result, this increased rate of ROS production can lead to vascular oxidative stress and other assorted pro-atherogenic events (not exactly ideal if you want to live a long time).[3]


Researchers found that supplementing with S7 was able to modify the “redox signaling” process in humans and significantly inhibit the production of mitochondrial and cellular reactive oxygen species, resulting in a 2.3-fold increase (230%) of bioavailable nitric oxide.[1]


Additionally, researchers also observed a significant decrease in TNF- alpha induced cellular inflammatory resistance. As you’re probably aware, TNF-alpha is an inflammatory cytokine (protein) that serves as a central regulator of inflammation in the body.

What is the Effective Dose of S7?

Based on the current study, 50mg of S7 is the dose recommended to significantly enhance endogenous NO production.

Where Can I Find S7?

You can find S7 (along with several other prominent pump boosters) in Performax Labs VasoMax.


VasoMax is a next generation stim-free pump powder delivering perfect pumps each and every time. In addition to providing the researched-backed dose of S7, VasoMax also provides other standout pump enhancers including VASO6, GlyerSize, and Taurine.


We’ve also added in three powerful nootropics in AlphaZone (the first fully-stable form of Alpha GPC) along with Huperzine A and KannaEase to provide heightened focus and concentration without the use of stimulants.


  1. Boris V. Nemzer, Christoph Centner, Denise Zdzieblik, Bruno Fink, John M. Hunter & Daniel König (2017): Oxidative stress or redox signalling – new insights into the effects of a proprietary multifunctional botanical dietary supplement, Free Radical Research, DOI: 10.1080/10715762.2017.1390228
  2. Dro, W., Immunochemistry, D., & Krebsforschungszentrum, D. (2002). Free Radicals in the Physiological Control of Cell Function, 47–95.
  3. Hsieh, H.-J., Liu, C.-A., Huang, B., Tseng, A. H. H., & Wang, D. L. (2014). Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. Journal of Biomedical Science, 21(1), 3.

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