Agmatine Sulfate: Improve Blood Flow & Endurance
What is Agmatine Sulfate?
Agmatine Sulfate, (also known as 4-aminobutyl)guanidine, is a metabolite of the amino acid L-Arginine. It is derived via decarboxylation (removal of carboxylic acid) and is considered to be a neurotransmitter and neuromodulator. Though there is a fair amount of research still needed to be done to determine the extent of agmatine’s mechanisms, it has been observed that it can inhibit N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors. Agmatine is most widely known and used for its ability to inhibit nitric oxide synthase enzymes, translating to an increase in nitric oxide levels.
What are the benefits of supplementing with Agmatine Sulfate?
As previously stated, the main mechanism that agmatine sulfate is supplemented for is to increase nitric oxide levels by inhibiting the nitric oxide synthase enzyme. Additionally, agmatine sulfate has been shown to produce mild reductions in heart rate and blood pressure by both central and peripheral mechanisms, aid in glomerular filtration rate and have nephroprotective effects in the kidneys and assist in blood glucose regulation.
When talking about the nitric oxide boosting properties of agmatine sulfate, this is beneficial for those interested in improving training performance and recovery. These elevated nitric oxide levels result in increased blood flow, enhanced nutrient delivery and oxygen transport to skeletal muscle tissue in addition to improving muscle pumps during training.
Agmatine sulfate also acts in the body as a imidazoline agonist which assists in regulating insulin secretion, pain modulation and the aforementioned neuromodulation/neuroprotection. There are also notes of agmatine acting as an imidazoline agonist leading to the release of luteinizing hormone via interaction with the hypothalamic tissues.
What does the research Say?
Here is a look at a few key studies on agmatine sulfate:
In regards to pain perception and inflammation, one study by fairbanks et al has shown agmatine to have dose-dependent effect for reducing inflammation and neuropathic pain. Another conducted by Keynan O et al. found that agmatine had a statistically significant potential to reduce perceived pain.
Agmatine also has shown promise in improving blood glucose and insulin. In a study conducted by Chang et al., agmatine was shown to assist in the reduction of blood glucose levels. Another study by Khan et al. further demonstrated agmatines ability to increase glucose uptake into the muscle tissue.
Another positive effect that agmatine sulfate appears to positively influence is the regulating the negative effects of stress. In a study conducted by Aricioglu, agmatine has been shown to play a vital role in the brain’s ability to cope with stress.
Now, the most prominent area for which agmatine is used for is nitric oxide modulation and in turn, muscle pumps. Agmatine has been shown to positively regulate nitric oxide synthase resulting in improved vasodilation and pumps in studies conducted by Joshi et al. and Haluca et al. Furthermore, in a study by Biolo, agmatine has been shown to also have strong, positive impacts on protein synthesis, increased nutrient delivery and an overall increase in the rate of muscle tissue growth.
What is the best time to take Agmatine Sulfate? How much do I take?
The best time to take agmatine sulfate is 30-45 minutes before your training session for those looking to maximize blood flow for nutrient delivery and pumps. For those looking to utilize it for its analgesic effects, it may be taken in divided doses, multiple times a day. It can be safely taken in doses of up to 2500mg (2.5g) a day.
Are there any adverse side effects?
Though agmatine has been shown in some studies to improve gastrointestinal health, it should be noted that in rare cases some individuals may experience gastrointestinal discomfort, though this was typically observed in individuals taking amounts greater than 3.5g a day. Additionally, since agmatine does improve vasodilation, this can cause a drop in blood pressure so those with already low blood pressure should use caution when using agmatine. In general, it is advised you check with your healthcare provider if you are taking any over the counter or prescription medication before use.
Agmatine Sulfate is a fantastic compound that has a wide array of benefits from increasing blood flow, nutrient delivery and pumps while being able to decrease inflammation and perceived pain. To summarize, agmatine sulfate has been shown to aid in the following:
Positively regulate nitric oxide synthase
Increase nutrient delivery to muscle tissue
Reduce blood glucose levels
Improve glucose uptake into muscle tissue
Combat negative effects of stress
Ready to try Agmatine Sulfate?
Agmatine sulfate can be found in Performax’s innovative and potent pre-workout PowerMaxXT. The full clinical doses of clinically validated ingredients found in PowerMaxXT work in synergy to amplify size, strength, power, endurance and produce massive pumps. When looking for a comprehensive and extremely effective pre-workout, look no further than PowerMaxXT from industry-leading Performax.